The noticed insufficient an important accumulation of PHN in brain next the intraventricular administration of (+)-amphetamine along with the formation of considerable quantities of PHN from (+)-POH in Mind tissue in vivo supports the look at the aromatic hydroxylation of amphetamine adhering to its systemic administration takes place predominantly in the periphery, Which POH is then transported in the blood-Mind barrier, taken up by noradrenergic neurones in Mind where (+)-POH is converted in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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